About Center for System Genomics
The Center for Systems Genomics (CSG) was established in January of 2012 to bring together faculty interested in Systems Genomics at Pennsylvania State University. The research mission of the CSG is to integrate variation in DNA sequence, structural variation, gene expression, metabolomic, epigenetic, and proteomic data along with the environment to explore and dissect the genomic architecture of complex traits, leading to improved understanding of the biology and etiology of disease. Other CSG activities include a weekly genomics seminar series, a weekly journal club, and an annual retreat.
Global increases in both common and rare copy number load associated with autism.
Girirajan S, Johnson RL, Tassone F, Balciuniene J, Katiyar N, Fox K, Baker C, Srikanth A, Yeoh KH, Khoo SJ, Nauth TB, Hansen R, Ritchie M, Hertz-Picciotto I, Eichler EE, Pessah IN, Selleck SB.
Hum. Mol. Genet. (2013) doi: 10.1093/hmg/ddt136
Identification of biologically relevant enhancers in human erythroid cells.
Su MY, Steiner LA, Bogardus H, Mishra T, Schulz VP, Hardison RC, Gallagher PG.
J Biol Chem. 2013 Mar 22;288(12):8433-44. doi: 10.1074/jbc.M112.413260. Epub 2013 Jan 22.
Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network.
Pendergrass SA, Brown-Gentry K, Dudek S, Frase A, Torstenson ES, Goodloe R, Ambite JL, Avery CL, Buyske S, Bůžková P, Deelman E, Fesinmeyer MD, Haiman CA, Heiss G, Hindorff LA, Hsu CN, Jackson RD, Kooperberg C, Le Marchand L, Lin Y, Matise TC, Monroe KR, Moreland L, Park SL, Reiner A, Wallace R, Wilkens LR, Crawford DC, Ritchie MD.
PLoS Genet. 2013 Jan;9(1):e1003087. doi: 10.1371/journal.pgen.1003087. Epub 2013 Jan 31.